ANALYSIS OF FUMONISINS: A REVIEW

Ngày nhận bài: 02-07-2025

Ngày xuất bản: 02-07-2025

DOI: https://doi.org/10.31817/tckhnnvn.2016.14.10.

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Số: Tập 14 Số 10 (2016)

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Anh, D. ., Varga-Visi, Éva ., & Zsolnai, A. . (2025). ANALYSIS OF FUMONISINS: A REVIEW. Tạp Chí Khoa học Nông nghiệp Việt Nam, 14(10). https://doi.org/10.31817/tckhnnvn.2016.14.10.

ANALYSIS OF FUMONISINS: A REVIEW

Dang Huu Anh (*) 1, 2, , Éva Varga-Visi 1, 2, , Attila Zsolnai 3,

  • Tác giả liên hệ: [email protected]
  • 1 Faculty of Veterinary Medicine, Vietnam National University of Agriculture,
  • 2 Faculty of Agricultural and Environmental Science , Kaposvár University, Guba Sándor 40., Kaposvár, H-7400, Hungary
  • 3 Faculty of Veterinary Medicine, Vietnam National University of Agriculture, Faculty of Agricultural and Environmental Science , Kaposvár University, Guba Sándor 40., Kaposvár, H-7400, Hungary

    • Từ khóa

    ELISA, fumonisin, phân tích, phương pháp sắc ký

    Tóm tắt


    Độc tố nấm mốc fumonisin được tạo ra chủ yếu bởi những loài nấm Fusarium và gây ảnh hưởng nghiêm trọng đến sức khỏe của động vật và người. Để phân tích định lượng và định tính fumonisin trong thức ăn và nguyên liệu sản xuất thức ăn, nhiều phương pháp đã được áp dụng như ELISA, sắc ký lớp mỏng (TLC), sắc ký hiệu năng cao (HPLC), sắc ký lỏng ghép đầu dò khối phổ (LC-MS) và sắc ký khí ghép đầu dò khối phổ (GC-MS). Hầu hết các phương pháp đều áp dụng để phân tích định lượng fumonisin nhóm B vì nhóm này xuất hiện nhiều hơn hẳn so với những nhóm khác. Bài tổng hợp này sẽ thảo luận những nguyên lý của phương pháp, đồng thời cũng phân tích những ưu điểm và giới hạn của phương pháp.

    Tài liệu tham khảo

    Abbas H.K., R.D. Cartwright, W.T. Shier, M.M. Abouzied, C.B. Bird, L.G. Rice, P.F. Ross, G.L. Sciumbato and F.I. Meredith (1998). Natural Occurrence of Fumonisins in Rice with Fusarium Sheath Rot Disease. Plant Disease, 82(1): 22 - 25.

    Aboul-Nasr M.B and M.R.A. Obield-Allah (2013). Biological and chemical detection of fumonisins produced on agar medium by Fusarium verticillioides isolates collected from corn in Sohag, Egypt. Microbiology, 159: 1720 - 1724.

    AOAC (2000). Chapter 49. Natural Toxins. Subchapter 5. Fumonisins. AOAC Official Method 995.15. In: Official Methods of Analysis of AOAC International, 17th edition. Horwiz, W. (Ed.), Gaithersburg, Maryland, USA.

    Arranz I., W.R.G. Baeyens, G. Weken, S. Saeger and C. Peteghem (2004). Review: HPLC determination of fumonisin mycotoxins. Critical Reviews in Food Science and Nutrition, 44(3): 195 - 203.

    Azcona-Olivera J.I., M.M. Abouzied, R.D Plattner and J.J. Pestka (1992). Production of Monoclonal Antibodies to the Mycotoxins Fumonisin B1, B2, B3. J. Agric. Food Chem., 40: 531 - 534.

    Bartók T., A. Szekeres, Á. Szécsi, M. Bartók and Á. Mesterházy (2008). A new type of fumonisin series appeared on the scene of food and feed safety. Cereal Research Communications, 36: 315 - 319.

    Bartók T., L. Tölgyesi, Á. Mesterházy, M. Bartók and Á. Szécsi (2010a). Identification of the first fumonisin mycotoxins with three acyl groups by ESI-ITMS and ESI-TOFMS following RP-HPLC separation: palmitoyl, linoleoyl and oleoyl EFB₁ fumonisin isomers from a solid culture of Fusarium verticillioides. Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment, 27(12): 1714 - 1723.

    Bartók T., L. Tölgyesi, A. Szekeres, M. Varga, R. Bartha, Á. Szécsi, M. Bartók and Á. Mesterházy (2010b). Detection and characterization of twenty-eight isomers of fumonisin B1 (FB1) mycotoxin in a solid rice culture infected with Fusarium verticillioides by reversed-phase high-performance liquid chromatography/electrospray ionization time-of-flight and ion trap mass spectrometry. Rapid Commun. Mass Spectrom., 24: 35 - 42.

    Bartók T., L. Tölgyesi, Á. Szécsi, Á. Mesterházy, M. Bartók, E. Gyimes and A. Véha (2014). Detection of Previously Unknown Fumonisin P Analogue Mycotoxins in a Fusarium verticillioides Culture by High-Performance Liquid Chromatography-Electrospray Ionization Time-of-Flight and Ion Trap Mass Spectrometry. Journal of Chromatographic Science, 52: 508 - 513.

    Chauhan R., J. Singh, T. Sachdev, T. Basu and B.D. Malhotra (2016): Recent advances in mycotoxins detection. Biosensors and Bioelectronics,

    : 532 - 545.

    D’Arco G., M. Fernández-Franzón, G. Font, P. Damiani and J. Mañes (2008). Analysis of fumonisins B1, B2 and B3 in corn-based baby food by pressurized liquid extraction and liquid chromatography/tandem

    mass spectrometry. Journal of Chromatography A,

    (1-2): 188 - 194.

    Dupuy J., P. Le Bars, H. Bouda, and J. Le Bars (1993): Thermostability of fumonisin B1, a mycotoxin from Fusarium moniliforme, in corn. Applied and Environmental Microbiology, 59(9): 2864 - 2867.

    Frisvad J.C., J. Smedsgaard, R.A. Samson, T.O. Larsen and U. Thrane (2007). Fumonisin B2 production by Aspergillus niger. J. Agric. Food Chem., 55(23): 9727 - 9732.

    Gazzotti T., B. Lugoboni, E. Zironi, A. Barbarossa, A. Serraino and G. Pagliuca (2009). Determination of fumonisin B1 in bovine milk by LC-MS/MS. Food Control, 20: 1171 - 1174.

    Gelderblom W. C., K. Jaskiewicz, W. F. Marasas, P. G. Thiel, R. M. Horak, R. Vleggaar and N. P. Kriek (1988). Fumonisins - novel mycotoxins with cancer promoting activity produced by Fusarium moniliforme. Appl. Environ. Microbiol.,

    (7): 1806 - 1811.

    Girolamo A.D., M. Pascale and A. Visconti (2011). Comparison of methods and optimization of the analysis of fumonisins B1 and B2 in masa flour, an alkaline cooked corn product. Food Additives and Contaminants, pp. 1 - 22.

    Hübner F., H. Harrer, A. Fraske, S. Kneifel and H. U. Humpf (2012). Large scale purification of B-type fumonisins using centrifugal partition chromatography (CPC). Mycotoxin Res., 28(1): 37 - 43.

    IARC monographs on the evaluation of carcinogenic risks to humans. (1993). Toxins derived from Fusarium moniliforme: fumonisins B1 and B2 and fusarin C. IARC, 56: 445 - 466

    Jackson M. A. and G. A. Bennett (1990). Production of Fumonisin B1 by Fusarium moniliforme NRRL 13616 in Submerged Culture. Applied and Environmental Microbiology, 2296 - 2298.

    Jia W., X. Chu, Y. Ling, J. Huang and J. Chang (2014). Muli-mycotoxin analysis in dairy products by liquid chromatography coupled to quadrulope orbitrap mass spectometry. Journal of Chromatography A, 1345: 107-114.

    Karbancioglu-Guler F. and D. Heperkan (2009). Comparison of enzyme linked immunoassay and high performance liquid chromatography for determination of fumonisin in dried Figures. Proc. Nat. Sci, Matica Srpska Novi Sad, 117: 37 - 43.

    Khayoon W. S., B. Saad, B. Salleh, N. A. Ismail, N. H. A. Manaf and A. A. Latiff (2010). A reversed phase high performance liquid chromatography method for the determination of fumonisins B1 and B2 in food and feed using monolithic column and positive confirmation by liquid chromatography/ tandem mass spectrometry. Analytica Chimica Acta, 679: 91 - 97.

    Krska R., E. Welzig and H. Boudra (2007). Analysis of Fusarium toxins in feed. Animal Feed Science and Technology, 137(3-4): 241 - 264.

    Lawrence J. F, B. Niedzwiadek and P. M. Scott (2000). Effect of temperature and solvent composition on extraction of fumonisins B1 and B2 from corn products. J AOAC Int., 83(3): 604 - 611.

    Lazzaro I., C. Falavigna, G. Galaverna, C. Dall’Asta and P. Battilani (2013). Cornmeal and starch influence the dynamic of fumonisin B, A and C production and masking in Fusarium verticillioides and F. proliferatum. International Journal of Food Microbiology, 166: 21- 27.

    Li C., Y. L. Wu, T. Yang and W. G. Huang-Fu (2012): Rapid Determination of Fumonisins B1 and B2 in Corn by Liquid Chromatography-Tandem Mass Spectrometry with Ultrasonic Extraction. Journal of Chromatographic Science, 50: 57 - 63.

    Liao C. D., J. W. Wong, K. Zhang, P. Yang, J. B. Wittenberg, M. W. Trucksess, D. G. Hayward, N. S. Lee and J. S. Chang (2015). Multi-mycotoxin analysis of finished grain and nut products using ultrahigh-performance liquid chromatography and positive electrospray ionization-quadrulope orbital ion trap high-resolution mass spectrometry. J. Agric. Food Chem., 63(37): 8314 - 8332.

    Mateo J. J., R. Mateo, M. J. Hinojo, A. Llorens and M. Jiménez (2002). Liquid chromatographic determination of toxigenic secondary metabolites produced by Fusarium strains. J Chromatogr. A, 955: 245 - 256.

    Meister U. (1999). Effect of extraction and extract purification on the measurable fumonisin content of maize and maize products. Tests on the efficiency of acid extraction and use of immunoaffinity columns. Mycotoxin Research, 15: 13 - 23.

    Mohanlall R., B. Odhav and V. Mohanlall (2013). The effect of thermal processing on fumonisin B1 (FB1) levels in maize-based foods. African Journal of Food Science. 7(3): 45 - 50.

    Muscarella M., S. L. Magro, D. Nardiello, C. Palermo, D. Centonze (2008): Development of a new analytical method for the determination of fumonisins B1 and B2 in food products based on high performance liquid chromatography and fluorimetric detection with post-column derivatization. Journal of Chromatography A, 1203: 88 - 93.

    Musser S. M. & R. D. Plattner (1997). Fumonisin composition in cultures of Fusarium moniliforme, Fusarium proliferatum and Fusarium nygami. J. Agric. Food Chem., 45(4): 1169 - 1173.

    Ndube N. (2011). Determination of fumonisins in maize by High Performance Liquid

    Chromatography with fluorescence and ultraviolet detection of ophthaldialdehyde, naphthalene-2,3-dicarboxaldehyde and dansyl chloride derivatives. MSc Chemistry Thesis, Department of Chemistry, University of the Western Cape.

    Ono E. Y. S., O. Kawamura, M. A. Ono, Y. Ueno and E. Y. Hirooka (2000). A Comparative Study of Indirect Competitive ELISA and HPLC for Fumonisin Detection in Corn of the State of Paraná, Brazil. Food and Agricultural Immunology, 12(1): 5 - 14.

    Pascale M. N. (2009). Detection methods for mycotoxins in cereal grains and cereal products. Zbornik Matice srpske za prirodne nauke, 117: 15 - 25.

    Pestka J. J., J. I. Azcona-Olivera, R. D. Plattner, F. Minervini, M. B. Doko and A. Visconti (1994). Comparative assessment of Fumonisin in grain-based foods by ELISA, GC-MS, and HPLC. Journal of Food Protection, 57(2): 169 - 172.

    Plattner R. D., P. F. Ross, J. Stedelin and L. G. Rice (1990). Analysis of corn and cultured corn for fumonisin B1 by HPLC and GC-MS by four laboratories. J. Vet. Diagn. Invest., 3: 357 - 358.

    Plattner R. D. and B. E. Branham (1994). Labeled Fumonisins: Production and Use of Fumonisin B1 Containing Stable Isotopes. Journal of AOAC International, 77(2).

    Poling S. M. and R. D. Plattner (1999). Rapid purification of fumonisins and their hydrolysis products with solid-phase extraction columns. J Agric Food Chem., 47(6): 2344 - 2349.

    Quan Y., Y. Zhang, S. Wang, N. Lee and I. R. Kenedy (2006). A rapid and sensitive chemiluminescence enzyme-linked immunosorbent assay for the determination of fumonisin B1 in food samples. Analytica Chimica Acta, 580: 1 - 8.

    Rheeder J. P., W.F.O. Marasas and H. F. Vismer (2002). Production of fumonisin analogs by Fusarium species. Applied and Environmental Microbiology, 68(5): 2101 - 2105.

    Romero-Gonzalez R., V.J.L. Martínez, M.M. Aquilera-Luiz and F.A. Garrido (2009). Application of conventional solid-phase extraction for multimycotoxin analysis in beers by ultrahigh-performance liquid chromatography-tandem

    mass spectrometry. J. Agric. Food. Chem.,

    (20): 9385 - 9392.

    Rottinghaus G. E., C. E. Coatney and H. C. Minor (1992). A rapid, sensitive thin layer chromatography procedure for the detection of fumonisin B1 and B2. J Vet Diagn Invest, 4: 326 - 329.

    Schaafsma A. W., R. W. Nicol, M. E. Savard, R.C. Sinha, L.M. Reid and G. Rottinghaus (1998): Analysis of Fusarium toxins in maize and wheat using thin layer chromatography. Micropathologia, 142: 107 - 113.

    Scott P. M., G. A. Lawrence and G. A. Lombaert (1999). Studies on extraction of fumonisins from rice, corn-based foods and beans. Mycotoxin Res., 15(2): 50 - 60.

    Sewram V., G. S. Shephard, W. F. Marasas, M. F. Penteado and M. de Castro (2003). Improving extraction of fumonisin mycotoxins from Brazilian corn-based infant foods. J Food Prot., 66(5): 854 - 859.

    Shephard O. S., E. W. Sydenham, P. O. Thiel and W. C. A. Oelderblom (1990). Quantitative determination of fumonisins B, and B2 by high pressure liquid chromatography with fluorescence detection. J. Liquid. Chromatogr., 13: 2077 - 2087.

    Shephard G. S. (1998). Chromatographic determination of the fumonisin mycotoxins. J. Chromatogr. A, 815: 31 - 39.

    Silva L., M. Fernández-Franzón, G. Font, A. Pena, I. Silveira, C. Lino and J. Mañes (2009). Analysis of fumonisins in corn-based food by liquid chromatography with fluorescence and mass spectrometry detectors. Food Chemistry, 112(4): 1031 - 1037.

    Stockenström S., E. W. Sydenham and P. G. Thiel (1994). Determination of fumonisins in corn: Evaluation of two purification procedures. Mycotoxin Research, 10(1): 9 - 14.

    Syndenham E. W., G. C. A. Gelderblom, P. G. Thiel and W.F.O. Marasas (1990). Evidence for the natural occurrence of fumonisin B1, a mycotoxin produced by Fusarium moniliforme, in corn. J. Agric. Food Chem., 38(1): 285 - 290.

    Szekeres A., A. Lorántfy, O. Bencsik, A. Kecskeméti, Á. Szécsi, Á. Mesterházy and C. Vágvölgyi (2012). Rapid purification method for fumonisin B1 using centrifugal partition chromatography, Food Additives & Contaminants: Part A.

    Tamura M., A. Uyama and N. Mochizuki (2011). Development of a multi-mycotoxin analysis in beer-based drinks by a modified quecher method and ultra-high-performance liquid chromatography coulple wit tandem mass spectrometry. Anal Sci., 27(6): 629 - 635.

    Tamura M., N. Mochizuki, Y. Nagatomi, A. Toriba and K. Hayakawa (2014). Characterization of Fumonisin A-Series by High-Resolution Liquid Chromatography-Orbitrap Mass Spectrometry. Toxins, (6): 2580 - 2593.

    Tamura M., N. Mochizuki, Y. Nagatomi, K. Harayama, A. Toriba and K. Hayakawa (2015). Identification and Quantification of Fumonisin A1, A2, and A3 in Corn by High-Resolution Liquid Chromatography-Orbitrap Mass Spectrometry. Toxins, 7: 582 - 592.

    Varga J., S. Kocsubé, K. Suri, G. Szigeti, A. Szekeres, M. Varga, B. Tóth and T. Bartók (2010). Fumonisin contamination and fumonisin producing black Aspergilli in dried vine fruits of different origin. International Journal of Food Microbiology, 143(3): 143 - 149.

    Voss K. A., G. W. Smith and W. M. Haschek (2007). Fumonisins: Toxicokinetics, mechanism of action and toxicity. Anim Feed Sci Technol, 137: 229 - 325.

    Voss K. A., R. T. Riley and J. G. Waes (2011). Fumonisins. Chapter 53. Reproductive and Development Toxicology, Edited by Ramesh C. Gupta ISBN: 978-0-12-382032-7

    Vrabcheva T., J. Stroka and E. Anklam (2002). Occurrence of fumonisin B1 in Bulgarian maize samples determined by ELISA and TLC methods using different clean up steps. Mycotoxin Res., 18(2): 46 - 56.

    Wilcox J., C. Donnelly, D. Leeman and E. Marley (2015). The use of immunoaffinity columns connected in tandem for selective and cost-effective mycotoxin clean-up prior to multi-mycotoxin liquid chromatographic-tandem mass spectrometric analysis in food matrices. Journal of Chromatography A, 1400: 91 - 97.

    Wu S., N. Duan, X. Li, G. Tan, X. Ma, Y. Xia, Z. Wang and H. Wang (2013). Homogenous detection of fumonisin B1 with a molecular beacon based on fluorescence resonance energy transfer between NaYF4: Yb, Ho upconversion nanaparicles and gold nanopaticles. Talanta, 116: 611 - 618.

    Yang X., X. Zhou, X. Zhang, Y. Qing, M. Luo, X. Liu, C. Li, Y. Li, H. Xia and J. Qiu (2015). A highly sensitive electro chemical immunosensor for fumonisin B1 detection in corn using sighle-walled carbon nanotubes/Chitosan. Electroanalysis, 27(11): 2679 - 2687.