Early Evaluation o GSTO1 Polymorphisms of in Fants with Pre-born Exposure to Arsenic

Date Received: 06-06-2025

Date Published: 13-06-2025

##submissions.doi##: https://doi.org/10.31817/tckhnnvn.2013.11.6.

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Issue: Vol. 11 No. 6 (2013)

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Binh, T., Thao, T., Thu, N., Duc, N., Lien, N., & Hoang, N. (2025). Early Evaluation o GSTO1 Polymorphisms of in Fants with Pre-born Exposure to Arsenic. Vietnam Journal of Agricultural Sciences, 11(6). https://doi.org/10.31817/tckhnnvn.2013.11.6.

Early Evaluation o GSTO1 Polymorphisms of in Fants with Pre-born Exposure to Arsenic

Ta Thi Binh , Tran Phuong Thao , Nguyen Thi Minh Thu , Nguyen Huu Duc , Nguyen Thi Kim Lien , Nguyen Huy Hoang (*)

  • Tác giả liên hệ: [email protected]

    • Keywords

    Arsenic exposure, GSTO1, PCR-RFLP, single nucleotide polymorphism

    Abstract


    In recent years, arsenic contamination as well as its effects on public health are increasingly becoming important and serious issues in worldwide, especially in developing countries. Glutathione S-transferase omega-1 (GSTO1) is a phase II enzymatic detoxification of xenobiotics in a variety of animals including humans, catalyzing the arsenic methylation. The efficiency of arsenic methylation is influenced by genetic polymorphisms at individual level. To assess the variations of single nucleotide polymorphisms of GSTO1, PCR-RFLP technique was ultilized. In this study, both SNP rs11509438 and SNP rs15032 in four studied samples were found homozygoous CC. These results may serve as basis for further studies on genetic polymorphisms of infants with pre-born arsenic exposure.

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