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• Early Evaluation o GSTO1 Polymorphisms of in Fants with Pre-born Exposure to Arsenic

  Ta Thi Binh, Tran Phuong Thao, Nguyen Thi Minh Thu, Nguyen Huu Duc, Nguyen Thi Kim Lien, Nguyen Huy Hoang

  Date Received: 26-04-2013 / Date Accepted: 22-08-2013 / Date Published: 13-06-2025

   Abstract PDF (VIETNAMESE)

  In recent years, arsenic contamination as well as its effects on public health are increasingly becoming important and serious issues in worldwide, especially in developing countries. Glutathione S-transferase omega-1 (GSTO1) is a phase II enzymatic detoxification of xenobiotics in a variety of animals including humans, catalyzing the arsenic methylation. The efficiency of arsenic methylation is influenced by genetic polymorphisms at individual level. To assess the variations of single nucleotide polymorphisms of GSTO1, PCR-RFLP technique was ultilized. In this study, both SNP rs11509438 and SNP rs15032 in four studied samples were found homozygoous CC. These results may serve as basis for further studies on genetic polymorphisms of infants with pre-born arsenic exposure.

  DOI: https://doi.org/10.31817/tckhnnvn.2013.11.6.