Ngày nhận bài: 02-03-2017 / Ngày duyệt đăng: 28-04-2017 / Ngày xuất bản: 06-08-2025
The aim of the present study was to examine the association of polymorphisms in the small nuclear RING finger protein (RNF4), retinol binding protein 4 (RBP4) and the insulin-like growth factors 2 (IGF2) genes with reproductive traits in Landrace and Yorkshire sows. A total 393 sows (188 Landrace and 205 Yorkshire) were genotyped using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The results found that the polymorphic sites of two polymorphisms in the RNF4 and RBP4 genes were found in both breeds (RNF4: TT, TC and CC; RBP4: AA, AB, BB genotype; IGF2: AB and BB), except the genotype AA of IGF2 was not observed in Yorkshire sows. The polymorphisms of RNF4 showed a significant association with total number of piglets born and the number of piglets born alive in both Landrace and Yorkshire sows (P < 0.05). Sows with the CC genotype produced more piglets than TT genotype. A significant association of the RNF4 polymorphism with total litter weight of piglet born was also observed in the Landrace sows (P < 0.05). For the RBP4 gene, there was a significant association between the genotypes with the number of piglets borm, total number born alive, and total litter birth weight in Landrace sows (P < 0.05). No significant association of the IGF2 polymorphism with any reproductive traits was observed in either Landrace or Yorkshire sows (P > 0.05). These results indicated that the RNF4 and RBP4 genes can be used as candidate genes for improvement of litter size traits in pigs.
