Date Received: 20-07-2017 / Date Accepted: 01-09-2017 / Date Published: 06-08-2025
Kudzu (Pueraria thomsoni Benth) is one of the popular crops in Vietnam. Kudzu roots are not only the food, but also have good healing properties. This study is aimed to test the effect of kudzu extract containing biological active ingredients on reducing sleeping time and blood alcohol concetration caused by drinking alcohol by mice. Kudzu extract using in this study having the biological active compound including puerarin, daidzin, daidzein were 184.32μg/ml; 42.46μg/ml; 20.60μg/ml respectively, determined by HPLC. The treated mice were divided into two groups consisting of the ones fed under the adequate diets conditions and the other unfed in 12-hour before drinking alcohol. The amounts of kudzu extract for the mice on testing the alcohol concentration were 0.2; 2.5; 3.0; 3.5; 4.0 ml/kg of body weight. The sleeping time of rats was determined immediately after the rat lost the ability to rotate to the left/right until they turned around back. Blood alcohol concentration was determined in accordance with the Decision No. 193 in 2010 by Ministry of Health. The result showed that between two groups of mice, the ones fed in normal diet had a minimum sleeping time of 40 minutes when taking kudzu extract at 4 ml/kg of body weight, whereas the controls drunk alcohol only, the duration of sleep was 108 minutes. In the rats unfed in 12-hour, the sleeping time also extended almost double. The result indicated that the alcohol concentration in blood of the group fed in normal diet was lower than that of unfed in 12-hour. Theamount of kudzu extract at 2ml/kg of body weight showed effect on a reduction of blood alcohol concentration in blood of both groups.
