TỔNG QUAN VỀ BỆNH DO VI KHUẨN Streptococcus iniae GÂY RA TRÊN CÁ BIỂN

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Thiết, N., Anh, K., Nhinh, Đoàn, & Hoài, T. (2025). TỔNG QUAN VỀ BỆNH DO VI KHUẨN Streptococcus iniae GÂY RA TRÊN CÁ BIỂN. Tạp Chí Khoa học Nông nghiệp Việt Nam, 23(8), 1126–1136. https://doi.org/10.31817/tckhnnvn.2025.23.8.14

TỔNG QUAN VỀ BỆNH DO VI KHUẨN Streptococcus iniae GÂY RA TRÊN CÁ BIỂN

Nguyễn Công Thiết 1 , Kim Minh Anh 1 , Đoàn Thị Nhinh 1 , Trương Đình Hoài (*) 1

  • Tác giả liên hệ: [email protected]
  • 1 Khoa Thuỷ sản, Học viện Nông nghiệp Việt Nam
  • Từ khóa

    Cá biển, cơ chế gây bệnh, độc lực, kháng kháng sinh, phòng và trị bệnh, Streptococcus iniae

    Tóm tắt


    Streptococcus iniae là tác nhân gây bệnh nghiêm trọng đã được báo cáo gây thiệt hại kinh tế cho người nuôi biển, đặc biệt đối với cá biển có giá trị kinh tế như cá chim vây vàng, cá chẽm, cá mú, cá dìa, cá giò, cá nâu. Cùng với những ca nhiễm Streptococcus iniae ở cá biển nuôi và cả cá ngoài tự nhiên được báo cáo trong và ngoài nước cho thấy sự cấp thiết trong việc tổng hợp thông tin giúp định hướng nghiên cứu, làm cơ sở đề ra các giải pháp quản lý dịch bệnh hiệu quả, giảm thiểu thiệt hại kinh tế cho nghề nuôi cá biển tại Việt Nam. Bài tổng quan này phân tích cơ chế gây nhiễm, các yếu tố độc lực, tình trạng kháng kháng sinh và thực trạng kiểm soát bệnh trên cá biển do vi khuẩn S. iniae gây ra liên quan đến nghiên cứu và sử dụng vacxin, probiotics, tinh dầu thảo dược trong việc tăng cường hệ miễn dịch và kháng bệnh của cá biển lên tác nhân gây bệnh nguy hiểm này, đồng thời chỉ ra những triển vọng và định hướng nghiên cứu tiếp theo liên quan đến bệnh do vi khuẩn S. iniae gây ra trên cá biển tại Việt Nam.

    Tài liệu tham khảo

    Abdelbaky A.A., Soliman A.W., Abdelsalam M., Aboulezz A.S., Abou-Okada M., Sharaf M.S., El-Demerdash G.O., Eldessouki E.A. & Eissa A.E. (2021). Genotypic characterization of some dermotropic and systemic bacterial pathogens affecting two commercial Red Sea fishes. Egyptian Journal of Aquatic Biology & Fisheries. 25(6).

    Agnew W. & Barnes A.C. (2007). Streptococcus iniae: An aquatic pathogen of global veterinary significance and a challenging candidate for reliable vaccination. Veterinary Microbiology. 122(1): 1-15.

    Akhter N., Wu B., Memon A.M. & Mohsin M. (2015). Probiotics and prebiotics associated with aquaculture: a review. Fish & Shellfish Immunology. 45(2): 733-741.

    Avrilia D., Suprapto H. & Rahardja B.S. (2022). Evaluation of Histopathological Changes in Cantang Groupers’ Brain and Gill Infected with Streptococcus iniae. World's Veterinary Journal. (1): 87-94.

    Awate S., Mubarka S. & Huber R. G. (2023). Whole genomic characterization of Streptococcus iniae isolates from barramundi (Lates calcarifer) and preliminary evidence of cross-protective immunization. Vaccines. 11(9): 1443.

    Baiano J.C. & Barnes A.C. (2009). Towards control of Streptococcus iniae. Emerging Infectious Diseases. 15(12): 1891.

    Baiano J.C., Tumbol R. A., Umapathy A. & Barnes A.C. (2008). Identification and molecular characterisation of a fibrinogen binding protein from Streptococcus iniae. BMC Microbiology. 8: 1-16.

    Bromage E., Thomas A. & Owens L. (1999). Streptococcus iniae, a bacterial infection in barramundi Lates calcarifer. Diseases of Aquatic Organisms. 36(3): 177-181.

    Bromage E. & Owens L. (2009). Environmental factors affecting the susceptibility of barramundi to Streptococcus iniae. Aquaculture. 290(3-4): 224-228.

    Buschmann A.H., Tomova A., López A., Maldonado M.A., Henríquez L.A., Ivanova L., Moy F., Godfrey H.P. & Cabello F.C. (2012). Salmon aquaculture and antimicrobial resistance in the marine environment. PLoS ONE. 7(8): e42724.

    Cain K. (2022). The many challenges of disease management in aquaculture. Journal of the World Aquaculture Society. 53(6): 1080-1083.

    Caputo A., Bondad‐Reantaso M.G., Karunasagar I., Hao B., Gaunt P., Verner‐Jeffreys D., Fridman S. & Dorado‐Garcia A. (2023). Antimicrobial resistance in aquaculture: A global analysis of literature and national action plans. Reviews in Aquaculture. 15(2): 568-578.

    Cho S. H. & Kim T. (2024). Fish Meal Substitution Effects with the Combined Animal Proteins in the Feeds of Olive Flounder (Paralichthys olivaceus) on Growth Performance, Feed Availability, and Disease Resistance against Streptococcus iniae. Animals. 14(8): 1162.

    Creeper J. & Buller N. (2006). An outbreak of Streptococcus iniae in barramundi (Lates calcarifera) in freshwater cage culture. Australian Veterinary Journal. 84(11).

    Deng M., Yu Z.h., Geng Y., Wang K., Chen D., Huang X., Ou Y., Chen Z., Zhong Z. & Lai W. (2017). Outbreaks of Streptococcosis associated with Streptococcus iniae in Siberian sturgeon (Acipenser baerii) in China. Aquaculture Research. 48(3): 909-919.

    Deng Y., Lin Z., Xu L., Jiang J., Cheng C., Ma H. & Feng J. (2024). A first report of Streptococcus iniae infection of the spotted sea bass (Lateolabrax maculates). Frontiers in Veterinary Science. 11: 1404054.

    Diaz J.H. (2014). Skin and soft tissue infections following marine injuries and exposures in travelers. Journal of Travel Medicine. 21(3): 207-213.

    Done H.Y., Venkatesan A.K. & Halden R.U. (2015). Does the recent growth of aquaculture create antibiotic resistance threats different from those associated with land animal production in agriculture?. The AAPS journal. 17: 513-524.

    Ethica S.N., Sri D., Sri S.D. & Sulistyaningtyas A.R. (2023). Streptolysin encoding genes sagC and sagD as biomarkers of fish pathogen Streptococcus iniae: an in silico study. Squalen Bull. of Mar. and Fish. Postharvest and Biotech. 15(1): 31-39

    Evans J., Klesius P., Shoemaker C. & Pasnik D. (2006). Identification and epidemiology of Streptococcus iniae and S. agalactiae. International Symposium on Talipia in Aquaculture. International Symposium on Talipia in Aquaculture. September 6-8, 2006. Veracruz, Mexico.

    Evans J.J., Shoemaker C.A. & Klesius P.H. (2001). Distribution of Streptococcus iniae in hybrid striped bass (Morone chrysops× Morone saxatilis) following nare inoculation. Aquaculture. 194(3-4): 233-243.

    Eyngor M., Chilmonczyk S., Zlotkin A., Manuali E., Lahav D., Ghittino C., Shapira R., Hurvitz A. & Eldar A. (2007). Transcytosis of Streptococcus iniae through skin epithelial barriers: an in vitro study. FEMS Microbiology Letters. 277(2): 238-248.

    Feng Y., Bai M., Geng Y., Chen D., Huang X., Ouyang P., Guo H., Zuo Z., Huang C. & Lai W. (2021). The potential risk of antibiotic resistance of Streptococcus iniae in sturgeon cultivation in Sichuan, China. Environmental Science and Pollution Research. 28: 69171-69180.

    Gnanagobal H. & Santander J. (2022). Host–pathogen interactions of marine gram-positive bacteria. Biology. 11(9): 1316.

    Griffin D.W., Banks K., Gregg K., Shedler S. & Walker B.K. (2020). Antibiotic resistance in marine microbial communities proximal to a Florida sewage outfall system. Antibiotics. 9(3): 118.

    Heckman T.I. (2021). Understanding and controlling the widespread piscine pathogen Streptococcus iniae. Dissertation. University of California, Davis. pp137.

    Huang H.-Y., Chen Y.-C., Wang P.-C., Tsai M.-A., Yeh S.-C., Liang H.-J. & Chen S.-C. (2014). Efficacy of a formalin-inactivated vaccine against Streptococcus iniae infection in the farmed grouper Epinephelus coioides by intraperitoneal immunization. Vaccine. 32(51): 7014-7020.

    Kim D., Beck B.R., Heo S.-B., Kim J., Kim H.D., Lee S.-M., Kim Y., Oh S.Y., Lee K. & Do H. (2013). Lactococcus lactis BFE920 activates the innate immune system of olive flounder (Paralichthys olivaceus), resulting in protection against Streptococcus iniae infection and enhancing feed efficiency and weight gain in large-scale field studies. Fish & Shellfish Immunology. 35(5): 1585-1590.

    Kim J.-H., Kim S.-B., Hwang H.-J., Kim Y.-M. & Lee M.-S. (2016). Antibacterial property of Ecklonia cava extract against marine bacterial pathogens. Journal of Food Hygiene and Safety. 31(5): 380-385.

    Kolar S.L., Kyme P., Tseng C.W., Soliman A., Kaplan A., Liang J., Nizet V., Jiang D., Murali R. & Arditi M. (2015). Group B Streptococcus evades host immunity by degrading hyaluronan. Cell Host & Microbe. 18(6): 694-704.

    Kumar A., Middha S.K., Menon S.V., Paital B., Gokarn S., Nelli M., Rajanikanth R. B., Chandra H.M., Mugunthan S.P. & Kantwa S.M. (2024). Current challenges of vaccination in fish health management. Animals. 14(18): 2692.

    Lalumera G.M., Calamari D., Galli P., Castiglioni S., Crosa G. & Fanelli R. (2004). Preliminary investigation on the environmental occurrence and effects of antibiotics used in aquaculture in Italy. Chemosphere. 54(5): 661-668.

    Lan N.G.T., Salin K.R., Longyant S., Senapin S. & Dong H.T. (2021). Systemic and mucosal antibody response of freshwater cultured Asian seabass (Lates calcarifer) to monovalent and bivalent vaccines against Streptococcus agalactiae and Streptococcus iniae. Fish & Shellfish Immunology. 108: 7-13.

    Lau S.K., Woo P.C., Tse H., Leung K.-W., Wong S.S. & Yuen K.-Y. (2003). Invasive Streptococcus iniae infections outside North America. Journal of Clinical Microbiology. 41(3): 1004-1009.

    Li W., Lim C.H., Zhao Z., Wang Y., Conway P.L. & Loo S.C.J. (2024). In vitro profiling of potential fish probiotics, Enterococcus hirae strains, isolated from jade perch, and safety properties assessed using whole genome sequencing. Probiotics and Antimicrobial Proteins. 1-14.

    Liu C.-H., Chiu C.-H., Wang S.-W. & Cheng W. (2012). Dietary administration of the probiotic, Bacillus subtilis E20, enhances the growth, innate immune responses, and disease resistance of the grouper, Epinephelus coioides. Fish & Shellfish Immunology. 33(4): 699-706.

    Locke J.B. (2008). Characterization of virulence factors in the aquatic pathogen Streptococcus iniae. Thesis, UC San Diego.

    Locke J.B., Aziz R.K., Vicknair M.R., Nizet V. & Buchanan J.T. (2008). Streptococcus iniae M-like protein contributes to virulence in fish and is a target for live attenuated vaccine development. Plos one. 3(7): e2824.

    Locke J.B., Colvin K.M., Datta A.K., Patel S.K., Naidu N.N., Neely M.N., Nizet V. & Buchanan J.T. (2007a). Streptococcus iniae capsule impairs phagocytic clearance and contributes to virulence in fish. Journal of Bacteriology. 189(4): 1279-1287.

    Locke J.B., Colvin K.M., Varki N., Vicknair M.R., Nizet V. & Buchanan J.T. (2007b). Streptococcus iniae â-hemolysin streptolysin S is a virulence factor in fish infection. Diseases of Aquatic Organisms. 76(1): 17-26.

    Lulijwa R., Rupia E.J. & Alfaro A.C. (2020). Antibiotic use in aquaculture, policies and regulation, health and environmental risks: a review of the top 15 major producers. Reviews in Aquaculture. 12(2): 640-663.

    Ma J., Wu H., Ma Z. & Wu Z. (2024). Bacterial and Host Factors Involved in Zoonotic Streptococcal Meningitis. Microbes and Infection. 105335.

    Maldonado M.J.J., Castillo P.L.J., Ponce H.A. & Carranza Á.C. (2022). Summary of economic losses due to bacterial pathogens in aquaculture industry. In Bacterial fish diseases. Elsevier: 399-417.

    Mcnulty S.T., Klesius P.H., Shoemaker C.A. & Evans J.J. (2003). Streptococcus iniae infection and tissue distribution in hybrid striped bass (Morone chrysops× Morone saxatilis) following inoculation of the gills. Aquaculture. 220(1-4): 165-173.

    Membrebe J.D., Yoon N.-K., Hong M., Lee J., Lee H., Park K., Seo S.-h., Yoon I., Yoo S. & Kim Y.-C. (2016). Protective efficacy of Streptococcus iniae derived enolase against Streptococcal infection in a zebrafish model. Veterinary Immunology and Immunopathology. 170: 25-29.

    Miranda C.D., Godoy F. A. & Lee M.R. (2018). Current status of the use of antibiotics and the antimicrobial resistance in the Chilean salmon farms. Frontiers in microbiology. 9: 1284.

    Mishra S., Seshagiri B., Rathod R., Sahoo S.N., Choudhary P., Patel S., Behera D.K., Ojha D.K., Jena A. & Namburu P.K. (2023). Recent advances in fish disease diagnosis, therapeutics, and vaccine development. Frontiers in Aquaculture Biotechnology. 115-145.

    Mohammadi Y., Mesbah M., Dezfoulnejad M.C., Mehrgan M.S. & Islami H.R. (2021). Growth performance, blood biochemical parameters, immune response, and antioxidant defense of Asian seabass (Lates calcarifer) fingerlings exposed to monovalent and bivalent vaccines against Streptococcus iniae and Vibrio harveyi. Aquaculture International. 29: 2751-2767.

    Muhammad M., Zhang T., Gong S., Bai J., Ju J., Zhao B. & Liu D. (2020). Streptococcus iniae: a growing threat and causative agent of disease outbreak in farmed Chinese sturgeon (Acipenser sinensis). Pakistan Journal of Zoology. 52(5): 1931.

    Namrudi S., Siahkalroodi S.Y., Hajibaglu A. & Mazandarani M. (2023). Effects of two-strain streptococcosis vaccine Streptococcus iniae/Lactococcus garvieae on some serum immune parameters in Rainbow trout (Oncorhynchus mykiss). Animal Environment Journal. 15(2): 205-212.

    Nguyen K.C.T., Truong P.H., Thi H.T., Ho X.T. & Van Nguyen P. (2024). Prevalence, multidrug resistance, and biofilm formation of Vibrio parahaemolyticus isolated from fish mariculture environments in Cat Ba Island, Vietnam. Osong Public Health and Research Perspectives. 15(1): 56.

    Ortega C., García I., Irgang R., Fajardo R., Tapia‐Cammas D., Acosta J. & Avendaño‐Herrera R. (2018). First identification and characterization of Streptococcus iniae obtained from tilapia (Oreochromis aureus) farmed in Mexico. Journal of Fish Diseases. 41(5): 773-782.

    Pan J.-M., Guo H.-Y., Liu B.-S., Zhang N., Xian L., Zhu T.-F., Zhu K.-C. & Zhang D.-C. (2024). Characterization of the Galectin-3 gene and its association with Streptococcus iniae resistance traits in Acanthopagrus latus (Houttuyn, 1782). Aquaculture. 593: 741364.

    Pérez Zamora C.M., Torres C.A. & Gonzalez A.M. (2023). Strategies to Improve Antimicrobial Activity of Natural Products: Approaches and Challenges. Bioprospecting of Tropical Medicinal Plants. 1265-1298.

    Pier G.B. & Madin S.H. (1976). Streptococcus iniae sp. nov., a beta-hemolytic streptococcus isolated from an Amazon freshwater dolphin, Inia geoffrensis. International Journal of Systematic and Evolutionary Microbiology. 26(4): 545-553.

    Qin Y., Ren X., Zhang Y., Ju H., Liu J., Xie J., Altaf M. M. & Diao X. (2024). Distribution characteristics of antibiotic resistance genes and microbial diversity in the inshore aquaculture area of Wenchang, Hainan, China. Science of The Total Environment. 914: 169695.

    Rohani M.F., Islam S.M., Hossain M.K., Ferdous Z., Siddik M.A., Nuruzzaman M., Padeniya U., Brown C. & Shahjahan M. (2022). Probiotics, prebiotics and synbiotics improved the functionality of aquafeed: Upgrading growth, reproduction, immunity and disease resistance in fish. Fish & Shellfish Immunology. 120: 569-589.

    Rudenko O., Engelstädter J. & Barnes A.C. (2020). Evolutionary epidemiology of Streptococcus iniae: Linking mutation rate dynamics with adaptation to novel immunological landscapes. Infection, Genetics and Evolution. 85: 104435.

    Sapkota A., Sapkota A.R., Kucharski M., Burke J., Mckenzie S., Walker P. & Lawrence R. (2008). Aquaculture practices and potential human health risks: current knowledge and future priorities. Environment International. 34(8): 1215-1226.

    Soltani M., Ghodratnama M., Taheri M.A., Zargar A. & Rouhollahi S. (2013). The effect of Zataria multiflora Boiss. and Rosmarinus officinalis essential oil on Streptococcus iniae isolated from rainbow trout farms. Aquaculture. 430: 248-252.

    Tacon A.G. (2023). Contribution of fish and seafood to global food and feed supply: An analysis of the FAO food balance sheet for 2019. Reviews in Fisheries Science & Aquaculture. 31(2): 274-283.

    Tafi A.A., Meshkini S., Tukmechi A., Alishahi M. & Noori F. (2020). Determination of component and in vitro antistreptococcal Properties of Mentha piperita L., Satureja khuzistanica Jamzad, Matricaria recutica L., Zataria multiflora Boiss and Rosmarinus officinalis L. ethanolic extracts. Iranian Journal of Fisheries Sciences. 19(3): 1373-1383.

    Thanasaksiri K., Fukuda K., Tsubone S., Miyadai H., Murakami T., Murakami A. & Takano R. (2018). Efficacy of a bivalent inactivated vaccine against red seabream iridovirus and Streptococcus iniae in red seabream, Pagrus major. Aquaculture. 492: 132-136.

    Thornber K., Bashar A., Ahmed M.S., Bell A., Trew J., Hasan M., Hasan N.A., Alam M.M., Chaput D.L. & Haque M.M. (2022). Antimicrobial resistance in aquaculture environments: unravelling the complexity and connectivity of the underlying societal drivers. Environmental Science & Technology. 56(21): 14891-14903.

    Tran Vi Hich, Vu Dang Ha Quyen, Nguyen Huu Dung & Wergeland H. I. (2013). Experimental Streptococcus iniae infection in barramundi (Lates calcarifer) cultured in Vietnam. Int. J. of Aquatic Science. 4(1): 3-12.

    Trương Thị Hoa, Đặng Thị Hoàng Oanh & Nguyễn Ngọc Phước (2018). Nghiên cứu đặc điểm bệnh học của vi khuẩn Streptococcus iniae trên cá chẽm (Lates calcarifer). Tạp chí Khoa học Đại học cần Thơ. 54(3): 156-163.

    Trần Vĩ Hích & Nguyễn Thị Kim Cúc (2020). Đánh giá hiệu quả của vaccine bất hoạt phòng bệnh mù mắt do liên cầu khuẩn gây ra ở cá bớp nuôi tại Khánh Hòa. Tạp chí Khoa học-Công nghệ Thủy Sản, Trường Đại học Nha Trang. (01): 054-058.

    Tumree P., Bunnoy A., Tang X. & Srisapoome P. (2024). Efficacy of whole-cell-based monovalent and bivalent vaccines against Streptococcus iniae and Flavobacterium covae in fingerling Asian seabass (Lates calcarifer). Fish & Shellfish Immunology. 144: 109269.

    Uchuwittayakul A., Thangsunan P., Thangsunan P., Rodkhum C. & Srisapoome P. (2024). Molecular structure and functional responses of IgM, IgT and IgD to Flavobacterium covae and Streptococcus iniae infection in Asian seabass (Lates calcarifer Bloch, 1790). Fish & Shellfish Immunology. 153: 109823.

    Wang B., Thompson K.D., Wangkahart E., Yamkasem J., Bondad‐Reantaso M.G., Tattiyapong P., Jian J. & Surachetpong W. (2023). Strategies to enhance tilapia immunity to improve their health in aquaculture. Reviews in Aquaculture. 15: 41-56.

    Xiong X., Chen R. & Lai J. (2023). Comparative genomics analysis of Streptococcus iniae isolated from Trachinotus ovatus: novel insight into antimicrobial resistance and virulence differentiation. BMC Genomics. 24(1): 775.

    Zlotkin A., Hershko H. & Eldar A. (1998). Possible transmission of Streptococcus iniae from wild fish to cultured marine fish. Applied and environmental microbiology. 64(10): 4065-4067.