Date Received: 12-05-2025 / Date Accepted: 14-08-2025 / Date Published: 28-08-2025
Streptococcus iniae is a highly pathogenic microorganism that poses significant economic threats to marine aquaculture, notably impacting commercially valuable species such as snubnose pompano, seabass, groupers, and snappers. The recent emergence of new infection cases in both farmed and wild fish populations, domestically and internationally, underscores the urgent necessity for comprehensive data collection for the development of effective disease management strategies. Such measures are vital to reducing economic losses in Vietnam’s marine fisheries sector. This review explores the mechanisms of infection, virulence factors, antibiotic resistance, and the current approaches to disease control in marine fish affected by S. iniae. The review highlights ongoing research and practical applications involving vaccines, probiotics, and botanical products aimed at enhancing immunological defences and resistance against this pathogen. Furthermore, the review discusses future prospects and research directions pertinent to S. iniae infections in Vietnamese marine fish, thereby supporting the advancement of sustainable aquaculture practices and effective disease management.