Clinical Signs and Pathological Lesions in Pigs with PCV2 Associated - Postweaning Multisystemic Wasting Syndrome in Some Northern Provinces of Vietnam

Date Received: 02-07-2025

Date Published: 02-07-2025

Views

0

Downloads

0

Section:

CHĂN NUÔI – THÚ Y – THỦY SẢN

How to Cite:

Le, H., Giap, N., Anh, D., & Tiep, N. (2025). Clinical Signs and Pathological Lesions in Pigs with PCV2 Associated - Postweaning Multisystemic Wasting Syndrome in Some Northern Provinces of Vietnam. Vietnam Journal of Agricultural Sciences, 10(7). https://doi.org/10.31817/tckhnnvn.2012.10.7.

Clinical Signs and Pathological Lesions in Pigs with PCV2 Associated - Postweaning Multisystemic Wasting Syndrome in Some Northern Provinces of Vietnam

Huynh Thi My Le (*) , Nguyen Van Giap , Dang Huu Anh , Nguyen Ba Tiep

  • Tác giả liên hệ: [email protected]
  • Keywords

    Pigs, PCV2, postweaning multisystemic wasting syndrome

    Abstract


    The aim of this study was to determine the main clinical signs and pathological  lesions of pigs with PCV2 - associated PMWS. Thirty nine postweaning pigs with suspected PCV2-associated PMWS were collected from 16 farms in four Nothern provinces of Vietnam (Hanoi, Hoa Binh, Bac Giang and Hai Duong). Clinical signs included wasting with weight loss, ill-thrift and rough hair coat (100%), respiratory clinical signs (89.74%), jaundice (15.38%), diarrhea (23.08%), neurologic signs (10.26%) and dermatitis (20.51%). Gross lesion finding included body prominent backbone and swollen, hemorrhagic lympho nodes (ranging from 94.87% to 100%). Gross lesions could also be found in the tonsil (53.85%), lung (92.31%), liver (41.02%), kidney (30.77%), intestines (28.21%) and spleen (17.95%), and arthritis (7.69%). Microscopic lesions consisted of vasculitis and granulomatous inflammation with the forming of multinucleated giant cells in the lung, superficial inguinal lymph nodes, kidney and liver. Using nested PCR method, PCV2b antigen were positive in 94.87% of samples from suspected pigs.

    References

    Chae, C. (2004). Postweaning multisystemic wasting syndrome: a review of aetiology, diagnosis and pathology. The Veterinary Journal 168: 41-49.

    Fenaux, M., P. G. Halbur, M. Gill, T. E. Toth, and X. J. Meng (2000). Genetic characterization of type 2 Porcine circovirus (PCV-2) from pigs with Postweaning multisystemic wasting syndrome in different geographic regions of North America and development of a differential PCR-restriction fragment length polymorphism assay to detect and differentiate between infections with PCV-1 and PCV-2. J. Clin. Microbiol. 38:2494-2503.

    Gillespie, J., T. Opriessnig, X.J. Meng, K. Pelzer, and V. Buechner-Maxwell (2009). Porcine circovirus type 2 and porcine circovirus-associated disease. J Vet Intern Med 23, pp. 1151-1163

    Hoogland, M.J., Opriessnig T., P.G. Halbur (2006). Effects of adjuvants on porcine circovirus type 2-associated lesions. Journal of Swine Health and Production 14(3): 133-139.

    Nguyễn Thị Thu Hồng, Phan Hoàng Dũng, Đặng Hùng, Nguyễn Tiến Hà, Chris Morrissy (2006) Bước đầu khảo sát về tình hình nhiễm PCV2 trên đàn heo nuôi ở một số tỉnh thành phía Nam. Khoa học Kỹ thuật thú y, tập XIII, số 3, tr. 67- 69.

    Nguyễn Thị Thu Hồng, Lê Thị Thu Phương, Đặng Hùng, Nguyễn Ngọc Hải, Chris. J. Morrissy (2010). Khảo sát đáp ứng kháng thể sau tiêm phòng vacxin dịch tả heo trên heo con nhiễm circovirus heo typ 2 (PCV2). Khoa học Kỹ thuật thú y, tập XVII, số 6, tr. 11 - 16.

    Lâm Thị Thu Hương (2012). Bệnh tích và tỉ lệ nhiễm một số vi khuẩn công nhiễm trên heo mắc hội chứng gày còm sau cai sữa. Khoa học kỹ thuật Thú y tập XIX số 3, tr 26-32.

    Lam Thu Huong and Duong Chi Mai (2006). Detection of porcine circovirus from lesions of postweaning-pig with wasting disease at some farms in Ho Chi Minh city and some adjacent provinces. Proceedings of international workshop on Biotechnology in agriculture, Ho Chi Minh city Vietnam, pp. 65 - 67.

    Kim, D., Y. Ha, Y. Oh, and C. Chae (2010). Prevalence of porcine circovirus types 2a and b in pigs with and without post-weaning multi-systemic wasting syndrome. The Veterinary Journal 188:115-117

    Langohr, I.M., Stevenson G.W., Nelson E.A., Lenz S.D., HogenEsch H., Wei H., and R.M. Pogranichniy (2011). Vascular lesions in pigs experimentally infected with porcine circovirus type 2 serogroup B. Veterinary Pathology 47(1): 140-147

    Li, J., Yuan X., Zhang C., Miao L., Wu J., Shi J., Xu S., Cui S., Wang J, and H. Ai (2010). A mouse model to study infection against porcine circovirus type 2: viral distribution and lesions in mouse. Virology Journal 7: 158

    Opriessnig, T., Xiang-Jin M., Patrick G. Halbur, (2007). Porcine circovirus type 2-associated disease: Update on current terminology, clinical manifestations, pathogenesis, diagnosis, and intervention strategies. J Vet Invest 19, pp. 591-615.

    Rovira, A., Balasch M., Segales J., Garcia L., Planaduran J., Rosell C., Ellerbrok H., Mankertz A., Domingo M., (2002). Experimental inoculation of conventional pigs with porcine reproductive and respiratory syndrome virus and porcine circovirus 2. J. Virol 76, pp. 3232-3239.

    Tomás, A., Fernandes, L.T., Valero, O., Segalés, J., 2008. A meta-analysis on exper-imental infections with porcine circovirus type 2 (PCV2). Vet. Microbiol. 132 (3-4), 260-273.

    Yang, Jeong S., Dae S. Song, So Y. Kim, Kwang S. Lyoo, Bong K. Park (2003). Detection of porcine circovirus type 2 in feces of pigs with or without enteric disease by polymerase chain reaction. J Vet Diagn Invest 15, pp. 369-373.