ASSOCIATION OF POLYMORPHISMS IN THE RNF4, RBP4, AND IGF2 GENES WITH REPRODUCTIVE TRAITS IN LANDRACE AND YORKSHIRE SOWS

Ngày nhận bài: 02-03-2017

Ngày duyệt đăng: 28-04-2017

Ngày xuất bản: 06-08-2025

DOI: https://doi.org/10.31817/tckhnnvn.2017.15.3.

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Số: Tập 15 Số 3 (2017)

Chuyên mục:

CHĂN NUÔI – THÚ Y – THỦY SẢN

Cách trích dẫn:

Vinh, N., Luc, D., Thinh, N., Bo, H., Mai, H. ., & Ton, V. (2025). ASSOCIATION OF POLYMORPHISMS IN THE RNF4, RBP4, AND IGF2 GENES WITH REPRODUCTIVE TRAITS IN LANDRACE AND YORKSHIRE SOWS. Tạp Chí Khoa học Nông nghiệp Việt Nam, 15(3), 220–229. https://doi.org/10.31817/tckhnnvn.2017.15.3.

ASSOCIATION OF POLYMORPHISMS IN THE RNF4, RBP4, AND IGF2 GENES WITH REPRODUCTIVE TRAITS IN LANDRACE AND YORKSHIRE SOWS

Nguyen Thi Vinh (*) 1, 2 , Do Duc Luc 1, 2 , Nguyen Hoang Thinh 1, 2 , Ha Xuan Bo 1, 2 , Hoang Ngoc Mai 1, 2 , Vu Dinh Ton 1, 2

  • Tác giả liên hệ: [email protected]
  • 1 Faculty of Animal Science,
  • 2 Center for Interdisciplinary Research on Rural Development, Vietnam National University of Agriculture

    • Từ khóa

    IGF2, Landrace, reproductive performance, RNF4, RBP4, Yorkshire

    Tóm tắt


    The aim of the present study was to examine the association of polymorphisms in the small nuclear RING finger protein (RNF4), retinol binding protein 4 (RBP4) and the insulin-like growth factors 2 (IGF2) genes with reproductive traits in Landrace and Yorkshire sows. A total 393 sows (188 Landrace and 205 Yorkshire) were genotyped using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The results found that the polymorphic sites of two polymorphisms in the RNF4 and RBP4 genes were found in both breeds (RNF4: TT, TC and CC; RBP4: AA, AB, BB genotype; IGF2: AB and BB), except the genotype AA of IGF2 was not observed in Yorkshire sows. The polymorphisms of RNF4 showed a significant association with total number of piglets born and the number of piglets born alive in both Landrace and Yorkshire sows (P < 0.05). Sows with the CC genotype produced more piglets than TT genotype. A significant association of the RNF4 polymorphism with total litter weight of piglet born was also observed in the Landrace sows (P < 0.05). For the RBP4 gene, there was a significant association between the genotypes with the number of piglets borm, total number born alive, and total litter birth weight in Landrace sows (P < 0.05). No significant association of the IGF2 polymorphism with any reproductive traits was observed in either Landrace or Yorkshire sows (P > 0.05). These results indicated that the RNF4 and RBP4 genes can be used as candidate genes for improvement of litter size traits in pigs.

    Tài liệu tham khảo

    Buske B., Sternstein I., Reissmann M., Reinecke P. and Brockmann G. (2006). Analysis of association of GPX5, FUT1 and ESR2 genotypes with litter size in a commercial pig cross population. Archiv für Tierzucht., 49: 259 - 268.

    Campbell E. M., Nonneman D. J., Kuehn L. A. and Rohrer G. A. (2008). Genetic variation in the mannosidase 2B2 gene and its association with ovulation rate in pigs. Anim. Genet., 39: 515 - 519.

    Curtin D., Ferris H. A., Hakli M., Gibson M., Janne O. A., Palvimo J. J. and Shupnik M. A. (2004). Small nuclear RING finger protein stimulates the rat luteinizing hormone-beta promoter by interacting with Sp1 and steroidogenic factor-1 and protects from androgen suppression. Mol. Endocrinol.,

    : 1263 - 1276.

    Drogemuller C., Hamann H. and Distl O. (2001). Candidate gene markers for litter size in different German pig lines, J. Anim. Sci., 79(10): 2565 - 2570.

    Harney J. P., Ott T. L. and Bazer F. W. (1993). Retinol-biding protein gene expression in cyclic and pergmant endometrium of pigs, sheep and cattle. Biol. Reprod., 49: 1066 - 1073.

    Hirvonen-Santti S. J., Sriraman V., Anttonen M., Savolainen S., Palvimo J. J., Heikinheimo M., Richards J. S. and Janne O. A. (2004). Small nuclear RING finger protein expression during gonad development: regulation by gonadotropins and estrogen in the postnatal ovary. Endocrinol., 145: 2433 - 2444.

    Horák P., Mikova´ G., Urban T., Putnová L., Knoll A. and Dvora´K J. (2001). Association of polymorphism in the IGF2 gene with litter size in Black Pied Prestice pigs. Czech J Anim. Sci.,

    : 505 - 508.

    Jeon J. T., Carlborg O. and To ¨ Rnsten, A. (1999). A paternally expressed QTL affecting skeletal and cardiac muscle mass in pigs maps to the IGF2 locus. Nat. Genet., 21: 157 - 165.

    Kaiser F. J., Moroy T., Chang G. T., Horsthemke B. and Ludecke H. J. (2003). The RING finger protein RNF4, a co-regulator of transcription, interacts with the TRPS1 transcription factor. J. Biol. Chem., 278: 38780 - 38785.

    Knoll A., Putnova´ L., Dvora´K J. and Cepica S. (2000). A NciI PCR-RFLP within intron 2 of the porcine insulin-like growth factor 2 (IGF2) gene. Anim. Genet., 31: 150 - 151.

    Marantidis A., Laliotis G. P. and Avdi, M. (2015). Association of RBP4 genotype with phenotypic reproductive traits of sows. Genet. Res. Inter., 2016: 1 - 5.

    Moilanen A. M., Poukka H., Karvonen U., Hakli M., Janne O. A. and Palvimo J. J. (1998). Identification of a novel RING finger protein as a coregulator in steroid receptor-mediated gene transcription. Mol. Cell. Biol., 18(9): 5128 - 5139.

    Naqvi A. N. (2007). Application of molecular genetic technologies in livestock production: potentials

    for developing countries. Advan. Biol. Res.,

    (3-4): 72 - 84.

    Nezer C., Moreau L., Brouwers B., Coppieters W., Detilleux J., Hanset R., Karim L., Kvasz A., Leroy P. and Georges M. (1999). An imprinted QTL with major effect on muscle mass and fat deposition maps to the IGF2 locus. Nat. Genet., 21: 155 - 156.

    Niu B. Y., Ye L. Z., Li F. E., Deng C. Y., Jiang S. W., Lei M. G. and Xiong Y. Z. (2009). Identification of polymorphism and association analysis with reproductive traits in the porcine RNF4 gene. Anim. Reprod. Sci., 110(3-4): 283 - 292.

    Omelka R., Martiniaková M., Peškovičová D. and Bauerová M. (2008). Associations between RBP4/MspI polymorphism and reproductive traits in pigs: an application of animal model. J. Agrobiol., 25: 77 - 80.

    Poukka H., Aarnisalo P., Santti H., Janne O. A. and Palvimo J. J. (2000). Coregulator small nuclear RING finger protein (SNURF) enhances Sp1- and steroid receptor-mediated transcription by different mechanisms. J. Biol. Chem., 275: 571 - 579.

    Rothschild F. M., Messer L., Day L., Wales R., Short T., Southwood O. and Plastow G. (2000). Investigation of the retinol-binding protein 4 (RBP4) gene as a candidate gene for increased litter size in pigs. Mammal. Genom., 11(1): 75 - 77.

    Rothschild M. F. (1998). Analysis of new candidate genes for reproduction in the pig. Plant and Animak genome VI conference. San Diego. USA, W61.

    Saville B., Poukka H., Wormke M., Janne O. A., Palvimo J. J., Stoner M., Samudio I. and Safe S. (2002). Cooperative coactivation of estrogen receptor α in ZR-75 human breast cancer cells by SNURF and TATA-binding protein. J. Biol. Chem., 277: 2485 - 2497.

    Short T. H., Rothschild M. F., Southwood O. I., Mclaren D. G., De Vries A., Van Der Steen H., Eckardt G. R., Tuggle C. K., Helm J., Vaske D. A., Mileham A. J. and Plastow G. S. (1997). Effect of the estrogen receptor locus on reproduction and production traits in four commercial pig lines, J. Anim. Sci., 75(12): 3138 - 3142.

    Spotter A., Muller S., Hamann H. and Distl O. (2009). Effect of polymorphisms in the genes for LIF and RBP4 on litter size in two German pig lines. Reprod. Domest. Anim., 44(1): 100 - 105.

    Spötter A. and Distl O. (2006). Genetic approaches to the improvement of fertility traits in the pig. Veter. J., 172(2): 234 - 247.

    Terman A., Kmieć M., Polasik D. and Pradziadowicz K. (2007). Retinol binding protein 4 gene and reproductive traits in pigs. Arch. Tierz. Dummerstorf, 50: 181 - 185.

    Wang X., Wang A., Fu J. and Lin, H. (2006). Effects of ESR1, FSHB and RBP4 genes on litter size in a Large White and a Landrace Herd. Arch. Tierz. Dummerstorf, 49: 64 - 70.