In Vitro Anti - Bacterial Activity of Nanodrugs (Polyme - Ag - Fe3o4 - Antibiotics) on Bacterial Strains Caused Acute Hepatopancreas Necrosis Disease (Ahpnd) in Shrimp

Date Received: 03-07-2025

Date Published: 03-07-2025

##submissions.doi##: https://doi.org/10.31817/tckhnnvn.2017.15.7.

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Issue: Vol. 15 No. 7 (2017)

Section:

CHĂN NUÔI – THÚ Y – THỦY SẢN

How to Cite:

Lua, D., Van, K., & Thu, H. (2025). In Vitro Anti - Bacterial Activity of Nanodrugs (Polyme - Ag - Fe3o4 - Antibiotics) on Bacterial Strains Caused Acute Hepatopancreas Necrosis Disease (Ahpnd) in Shrimp. Vietnam Journal of Agricultural Sciences, 15(7). https://doi.org/10.31817/tckhnnvn.2017.15.7.

In Vitro Anti - Bacterial Activity of Nanodrugs (Polyme - Ag - Fe3o4 - Antibiotics) on Bacterial Strains Caused Acute Hepatopancreas Necrosis Disease (Ahpnd) in Shrimp

Dang Thi Lua (*) , Kim Van Van , Ha Phuong Thu

  • Tác giả liên hệ: [email protected]

    • Keywords

    AHPND, antibiotic, nanodrug, shrimp, Vibrio parahaemolyticus

    Abstract


    The study was carried out to determine in vitro anti-bacterial effects of nanodrugs (Polyme_Ag_Fe3O4_Antibotics) on bacterial strains caused acute hepatopancreatic necrosis disease (AHPND) in shrimp. The Vibrio parahaemolyticus strain KC12.020 was used in this study at concentration of 108 cfu/ml. Results showed that the inhibition zone against the AHPND-caused bacterial strain of the nanodug, Polyme_Ag_Fe3O4_Doxycylin, was about 17.25 mm when the tested antibiotic dose was equal to only one-half of the recommended dose of Doxycylin. The effective anti-bacterial effect of the nanodrug, Polyme_Ag_Fe3O4_Ciprofloxcin, was similar to the antibacterial activity of the Ciprofloxacin used alone (the inhibitory diameter was 16.25 mm) when the tested antibiotic dose was equal to one-fifth (1/5) of the dose of Ciprofloxacin is recommended. However, the Polyme_Ag_Fe3O4_Ciprofloxcin product will not be used for trial at farm level because its usage has recently been banned in aquaculture. Other nanodrugs, Polyme_Ag_Fe3O4_Oxytetracyclin, Polyme_Ag_Fe3O4_Doxycyclin, and Polyme_Ag_Fe3O4_Doxycyclin_Florphenicol, are needed to further study because they did not show clearly the antibacterial activities against AHPND-caused bacterial strain in this study. These results indicated the potential use of nanodrugs (Polyme_Ag_Fe3O4_Antibiotics) in treatment of AHPND in shrimp.

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